Erlanger is the area's primary trauma center and is operated by the Chattanooga-Hamilton County Hospital Authority. Erlanger’s medical campuses include Erlanger East, Erlanger North, and the downtown campus which also includes Children's Hospital at Erlanger. 

Parkridge Medical Center is located east of downtown in the Glenwood District and is run by Tri-Star Healthcare who also operates Parkridge East and Parkridge Valley Hospital, a behavioral health facility. 

CHI Memorial, owned by Catholic Health Initiatives, has acute care campuses located in downtown Chattanooga and Hixson along with an imaging center in Ooltewah and affiliated physician practices throughout the city.

Siskin HospitalHealthSouth Chattanooga, and Kindred Hospital Chattanooga offer rehabilitation and long term acute care.